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JANX013
- Development stage
- Phase 1
- Lead developer
- Janux Therapeutics
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
JANX013 is a CD28 co-stimulatory Tumor Activated Immunomodulator (TRACIr) being developed by Janux Therapeutics for the treatment of metastatic castration-resistant prostate cancer (mCRPC). It is designed as a PSMA-targeted biologic immunotherapy that utilizes a proprietary tumor-activated technology platform to stimulate the immune system through CD28 co-stimulation specifically within the tumor microenvironment. This mechanism is intended to enhance anti-tumor activity while minimizing systemic safety issues typically associated with CD28 activation. JANX013 is planned for clinical development in combination with JANX007, a PSMA-targeted T-cell engager, to provide a synergistic immune response against prostate cancer cells.
- Other names
- PSMAxCD28-TRACIrPSMAxCD-28-TRACIrPSMAxCD 28-TRACIrPSMA-TRACIr
02
Targets
CD28 (Cluster of Differentiation 28)PSMA (Prostate-specific membrane antigen)
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