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Japanese encephalitis vaccine + Typhoid Vi polysaccharide vaccine
- Development stage
- Unknown
- Lead developer
- Bharat Biotech
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Subcutaneous
01
Overview
This entry refers to the co-administration of a live attenuated Japanese encephalitis (JE) vaccine and a Typhoid Vi polysaccharide (Vi-PS) vaccine, specifically within the context of clinical research conducted by the University of Oxford. The combination is being evaluated in a Phase 4 randomized controlled trial (NCT05943327) in Thailand to determine if iron deficiency or iron fortification (via ferrous fumarate-fortified food) affects the immunogenicity of these vaccines. The Japanese encephalitis component is a live-attenuated vaccine that induces neutralizing antibodies against the JE virus, while the Typhoid Vi-PS component is a subunit vaccine containing the purified capsular polysaccharide of *Salmonella Typhi* to provide active immunity against typhoid fever.
- Other names
- Japanese encephalitis (JE) vaccineTyphoid Vi polysaccharide (Vi-PS) vaccineJE vaccine + Vi-PS vaccine
02
Targets
Vi polysaccharide-specific B-cell receptorVi antigen (Vi capsular polysaccharide)
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