jatrorrhizine

Jatrorrhizine is a naturally occurring isoquinoline alkaloid primarily isolated from medicinal plants such as Coptis chinensis and Enantia chlorantha. It is a bioactive compound with diverse pharmacological activities including neuroprotective, antimicrobial (antibacterial and antifungal), antiplasmodial (antiprotozoal), antioxidant, antidiabetic, antilipidemic/anti-obesity, anticancer/antitumor (including antiproliferative and antimetastatic effects), anti-inflammatory (notably via inhibition of NF-kappa B/NLRP3 inflammasome signaling), and central nervous system modulation. Mechanistically it exerts its effects through multiple pathways such as induction of apoptosis in cancer cells via caspase-mediated pathways or by targeting TNIK-mediated Wnt–β-catenin signaling to inhibit metastasis; it also modulates the Akt/eNOS pathway to improve endothelial function in diabetes and obesity models. Jatrorrhizine has shown efficacy in preclinical models for metabolic disorders like diabetes and hyperlipidemia as well as chronic atrophic gastritis induced by Helicobacter pylori infection. No clinical studies have been reported so far; most data are from in vitro or animal studies[1][4][5][7][10].

Other names

2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol3-hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-iumJatrorrhizine hydrochloride