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JAZF1 adenovirus vector
- Development stage
- Preclinical
- Lead developer
- Chongqing Medical University
- Modality
- Gene Therapies
- Administration
- Parenteral
01
Overview
JAZF1 adenovirus vector (Ad-JAZF1) is a recombinant adenoviral vector designed to overexpress juxtaposed with another zinc finger gene 1 (JAZF1). JAZF1 is a transcriptional co-repressor and nuclear receptor regulator implicated in glucose and lipid metabolism, insulin sensitivity, and chronic inflammation. In preclinical research, Ad-JAZF1 is utilized to investigate the metabolic effects of JAZF1 overexpression in various tissues, such as the hypothalamus, liver, and adipose tissue. Studies have shown that central or peripheral administration of Ad-JAZF1 can suppress hepatic glucose production, enhance insulin signaling, reduce triglyceride accumulation, and modulate inflammatory pathways, making it a valuable tool for studying type 2 diabetes, obesity, and hepatic steatosis.
- Other names
- adenovirus expressing JAZF1adenovirus-JAZF1adenovirus-JAZF-1adenovirus-JAZF 1recombinant adenovirus expressing JAZF1
02
Targets
TAK1 (Transforming growth factor beta–activated kinase 1)
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