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JCXH-113

Development stage: Preclinical
Lead developer: Immorna
Modality: Vaccine mRNA → mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, mRNA Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics

Overview

JCXH-113 is a therapeutic self-replicating RNA (srRNA) vaccine developed by Jiachen Xihai (Immorna Biotherapeutics) for the treatment of tuberculosis. The vaccine utilizes srRNA technology to encode a fusion of multiple Mycobacterium tuberculosis epitopes, aiming to induce a potent and sustained cellular immune response. By leveraging the self-amplifying nature of srRNA, the vaccine is designed to provide higher and longer-lasting antigen expression compared to conventional mRNA vaccines, potentially improving therapeutic outcomes for patients with TB. It is currently in the IND-enabling/preclinical stage of development.

Other names: JCXH-113-Jiachen Xihai-TB fusion multi-epitope antigen-srRNA vaccine-Tuberculosis (therapeutic)TB fusion multi-epitope antigen-srRNA vaccine

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