Drug intelligence / Profile preview

JH021

Development stage: Phase 1
Lead developer: Biotech Pharmaceutical
Modality: Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

JH021 is a bispecific monoclonal antibody designed to target both the epidermal growth factor receptor (EGFR) and the mesenchymal-epithelial transition factor (cMET). Developed by Biotech Pharmaceutical Co., Ltd., it is currently being evaluated in Phase I clinical trials for the treatment of advanced solid tumors. By simultaneously inhibiting EGFR and cMET signaling pathways, JH021 aims to overcome resistance mechanisms often associated with single-target therapies in various cancers, particularly those where both pathways are co-activated or where cMET amplification drives resistance to EGFR inhibitors.

Targets

FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)FCGRT (Neonatal crystallizable fragment receptor)MET (Mesenchymal-epithelial transition factor receptor)C1Q (Complement C1q)EGFR T790M (Epidermal growth factor receptor T790M mutant)

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