Drug intelligence / Profile preview

jiajian guipi tang

Development stage
Unknown
Lead developer
First Affiliated Hospital of Henan University of Chinese Medicine
Administration
Oral
01

Overview

Jiajian Guipi Tang is a modified Traditional Chinese Medicine (TCM) herbal decoction derived from the classic Guipi Tang formula. It is a complex mixture of botanical ingredients, typically including Codonopsis, Astragalus, Angelica, fried Atractylodes rhizome, Fu Shen (Poria cocos with pine root), longan meat, Zhizhi, and sour jujube kernel. The formulation is traditionally used to nourish the heart and spleen, calm the mind, and regulate qi. In clinical research, it has been studied for its ability to improve depressive symptoms and sleep quality, often in combination with standard antidepressants like escitalopram. Additionally, it is being investigated for its potential to improve language function in children with cblC type methylmalonic aciduria.

Other names
Jiajian Guipi TangJiajian Guipi decoctionModified Guipi Decoction加减归脾汤
02

Targets

DRD2 (Dopamine D2 Receptor)HTR3A (5-hydroxytryptamine receptor 3A)MAOA (Monoamine oxidase A)MAPK3 (Mitogen-activated protein kinase 1)GR (Glucocorticoid receptor)MOR (Mu opioid receptor)PDE4APDE4B (3',5'-cyclic-AMP phosphodiesterase 4B)PPARA (Peroxisome proliferator-activated receptor alpha)SERT (Sodium-dependent serotonin transporter)

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