Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Jian-Pi Bu-Shen Jie-Du-Fang
- Development stage
- Unknown
- Lead developer
- Xiyuan Hospital
- Administration
- Oral
01
Overview
Jian-Pi Bu-Shen Jie-Du-Fang (JPBS) is a traditional Chinese herbal medicine formula investigated for its role in cancer supportive care. It is being studied for its ability to help patients better tolerate chemotherapy by alleviating side effects. Specifically, in a phase III trial for colon cancer patients receiving CAPOX (capecitabine and oxaliplatin) chemotherapy, JPBS was shown to significantly improve the completion rate of planned chemotherapy cycles compared to a placebo. The formula reduced the incidence of vomiting but was associated with a higher incidence of thrombocytopenia. JPBS is derived from two classic TCM formulas, Liujunzi Decoction and Er’zhi Wan. Its proposed mechanisms include regulating the gut microbiome, protecting against gastrointestinal injury, and mitigating bone marrow suppression through cytokine interaction and reduction of c-myc expression.
- Brand names
- JianPi-BuShen
- Other names
- Jianpi Bushen DecoctionJianPi-BuShen Formula
02
Targets
TP53 (Cellular Tumor Antigen p53 R175H)BCL2L1 (B-cell lymphoma-extra large protein)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)
Beyond the preview
Go deeper on Jian-Pi Bu-Shen Jie-Du-Fang.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Jian-Pi Bu-Shen Jie-Du-Fang.