Drug intelligence / Profile preview

Jiangzhuo prescription

Development stage
Unknown
Lead developer
Shanghai University of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Jiangzhuo prescription (JZF) is a Traditional Chinese Medicine (TCM) herbal compound developed for the treatment of metabolic disorders, including hyperlipidemia, metabolic syndrome, and obesity-related complications. The prescription is typically categorized under the "lowering turbidity" (Jiangzhuo) therapeutic principle in TCM, which aims to clear pathological metabolites or "phlegm-dampness" from the body. Developed and studied primarily by researchers at the Shanghai University of Traditional Chinese Medicine, the formula is composed of several botanical extracts, including *Alisma orientale*, *Salvia miltiorrhizae*, *Crataegus pinnatifida*, *Cassia obtusifolia*, and *Curcuma longa*. In clinical trials, it has been evaluated for its ability to regulate lipid profiles (total cholesterol, triglycerides, and LDL-C), lower blood glucose, and reduce blood pressure, often compared against western medications like fenofibrate. The compound is intended to address the multi-faceted nature of metabolic syndrome through synergistic herbal interactions.

Other names
JiangzhuofangJiangzhuo formulaJiangzhuo recipeJiangzhuo decoctionJiang-Zhuo-Fang
02

Targets

PPARA (Peroxisome proliferator-activated receptor alpha)SREBP-1 / SREBF1 (SREBP-1)

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