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Jiannao pills
- Development stage
- Unknown
- Lead developer
- Shanghai Pharmaceuticals Group Qingdao Growful Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Jiannao pills (also known as Jiannao Wan) is a commercially available traditional Chinese medicine (TCM) formulation widely used to nourish the brain, enhance mental acuity, calm the heart, and soothe the spirit. It is prepared from a mixture of 19 medicinal materials, including *Angelicae sinensis radix*, *Bambusae concretio silicea*, *Cistanches herba*, *Ginseng radix et rhizome*, and *Schisandrae chinensis fructus*, with quality control standardized by HPLC measurement of Schisandrol A. Jiannao pills are approved in China for the treatment of memory loss, insomnia, palpitations, and mild cognitive impairment. Preclinical research has also demonstrated its potential therapeutic efficacy in depression and anxiety, with studies suggesting its mechanism of action involves the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, reduction of pro-inflammatory cytokines (such as IL-1β, IL-6, and TNF-α), and modulation of the gut microbiota, potentially mediated via the NF-κB/NLRP3 signaling pathway.
- Brand names
- GrowfulGuofeng
- Other names
- Healthy Brain PillsJNWJiannao PillsJiannao Wan
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