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jianpi huayu
- Development stage
- Unknown
- Lead developer
- Jiangsu Provincial Hospital of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Jianpi Huayu (JPHY) is a Traditional Chinese Medicine (TCM) formula developed by the Jiangsu Province Hospital of Chinese Medicine, specifically designed for the treatment of gastric cancer and gastric precancerous lesions (GPL). The formula is based on the TCM therapeutic principles of strengthening the spleen (Jianpi) and resolving blood stasis (Huayu). It typically comprises a complex mixture of herbal ingredients, including *Astragalus membranaceus* (Huangqi), *Atractylodes macrocephala* (Baizhu), *Curcuma phaeocaulis* (Ezhu), and *Salvia miltiorrhiza* (Danshen). Mechanistically, Jianpi Huayu exerts anti-tumor effects by inhibiting the proliferation of gastric cancer cells, inducing apoptosis, and suppressing tumor-associated angiogenesis. Research suggests it modulates several key signaling pathways, including the PI3K/Akt/mTOR and VEGF pathways, and may also regulate the expression of inflammatory cytokines and hypoxia-inducible factors in the tumor microenvironment.
- Brand names
- Jianpi Huayu Jiedu
- Other names
- Jianpi Huayu DecoctionJianpi Huayu FormulaJianpi Huayu GranuleJianpi Huayu Fang
02
Targets
AKT (RAC-alpha serine/threonine-protein kinase)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)VEGFA (Vascular endothelial growth factor A)
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