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Jianpi Huazhuo is a Traditional Chinese Medicine (TCM) herbal formula developed by researchers at The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine. It is specifically designed to treat nonalcoholic fatty liver disease (NAFLD) in patients characterized by a phlegm-dampness constitution according to TCM diagnostic principles. The formula aims to strengthen the spleen (Jianpi) and resolve turbidity (Huazhuo), addressing the underlying metabolic imbalances associated with hepatic steatosis. Clinical research, including metagenomic studies, has investigated its impact on the intestinal microecological environment and its efficacy in improving liver function and metabolic parameters in NAFLD patients by modulating the gut microbiota.
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