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Jianpi Jieyu Decoction is a traditional Chinese herbal formula primarily composed of Astragalus membranaceus and Radix Pseudostellariae[1]. It is used in Traditional Chinese Medicine (TCM) for its purported effects on strengthening the spleen and relieving depression. The formula is considered empirical, meaning it has been developed based on clinical experience rather than modern pharmacological research. Its mechanism of action is believed to involve modulation of neurotransmitter systems and improvement of gastrointestinal function according to TCM theory, but specific molecular targets are not well defined in Western biomedical terms[1]. It has been studied for efficacy and safety in patients with mild-to-moderate depression[2].
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