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Jianpi Qingre Huayu Recipe
- Development stage
- Preclinical
- Lead developer
- Guangzhou University of Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Jianpi Qingre Huayu Recipe (JQH) is a Traditional Chinese Medicine (TCM) herbal formula developed through collaboration between Guangzhou University of Traditional Chinese Medicine, Central South University, and Shenzhen Traditional Chinese Medicine Hospital. Administered orally, JQH is primarily indicated for the treatment of gastric ulcers and precancerous lesions of gastric cancer (PLGC), including chronic atrophic gastritis. The formula's therapeutic mechanism involves the modulation of multiple biological pathways, including the inhibition of Interleukin-8 (IL-8) and the regulation of the JAK-STAT, Wnt, p53, and vascular endothelial growth factor (VEGF) signaling pathways. These actions contribute to improved immune function, reduced inflammation, and the inhibition of the transformation from gastritis to gastric cancer. Network pharmacology has identified quercetin as a key active ingredient within the recipe.
- Other names
- JQHJianpi Qingre Huayu Formula
02
Targets
EGFR T790M (Epidermal growth factor receptor T790M mutant)HIF1A (Hypoxia-inducible factor 1-alpha)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)IL-6R (Interleukin-6 receptor subunit alpha)
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