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Jianpi Sanjie Recipe
- Development stage
- Unknown
- Lead developer
- Shanghai Municipal Hospital of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
Jianpi Sanjie Recipe is a traditional Chinese medicine (TCM) herbal formula used primarily in the prevention and treatment of drug resistance in colorectal cancer. It is administered as part of integrative therapy, often alongside chemotherapy, for patients with stage III and IV colorectal cancer who meet the diagnostic criteria for spleen deficiency syndrome. The precise composition of herbs in this recipe is not specified in the available sources, but it follows TCM principles aimed at strengthening the spleen ("Jianpi") and resolving accumulations or masses ("Sanjie"). The mechanism of action is not fully elucidated; however, similar TCM formulas have been shown to modulate immune responses, inhibit tumor proliferation and metastasis, induce apoptosis via mitochondrial pathways or death receptor pathways, regulate signaling pathways such as PI3K/Akt/mTOR or NF-κB, and potentially reduce multidrug resistance markers like MDR1 mRNA[1][2]. Clinical studies are ongoing to evaluate its efficacy specifically against drug resistance in colorectal cancer[1].
- Brand names
- Jianpi Sanjie Recipe
02
Targets
NF-κB
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