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Jianpi Xiaoji Recipe
- Development stage
- Preclinical
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Oral
01
Overview
Jianpi Xiaoji Recipe is a traditional Chinese medicine (TCM) herbal formula used primarily in the management of gastrointestinal tumors and as an adjunct to chemotherapy. The recipe is typically administered as a decoction and is designed to "strengthen the spleen" and "reduce accumulation," according to TCM theory. It has been studied for its potential benefits in cancer patients, particularly those undergoing chemotherapy, with reported effects including improved quality of life, reduced side effects from chemotherapy, and possible inhibition of tumor progression. Mechanistically, it may exert anti-tumor activity by modulating immune function, regulating cell proliferation pathways such as PI3K/AKT/mTOR or CDK1/PI3K/AKT signaling (as seen in related formulas), inducing apoptosis in cancer cells, blocking the cell cycle, suppressing extracellular vesicle-mediated expression of pro-metastatic factors like ITGBL1, inhibiting TNFAIP3-NF-kB pathway activity, reducing activation of cancer-associated fibroblasts (CAFs), and helping restore intestinal flora balance[1][2]. The specific herbal composition can vary but generally includes herbs aimed at supporting digestive function and counteracting tumor-related symptoms.
- Brand names
- Jianpi Xiaoji Recipe
- Other names
- Jianpi Xiaoji Decoction健脾消积方 (Chinese)
02
Targets
TNFAIP3 (Tumor necrosis factor alpha-induced protein 3)CDK1 (Cyclin-dependent kinase 1)
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