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Jianpi Yangxue Qufeng Compound

Development stage
Preclinical
Administration
Oral
01

Overview

Jianpi Yangxue Qufeng Compound (JPYXQFC) is a modern Chinese medicine formula widely used in the clinical treatment of atopic dermatitis and chronic eczema. It has demonstrated significant therapeutic effects, particularly in alleviating symptoms of atopic dermatitis. The mechanism of action involves inhibition of the TLR4/MyD88/NF-κB signaling pathway, leading to reduced expression of pro-inflammatory cytokines such as IL-6 and TNF-α, decreased serum IgE levels, and improved skin barrier function by upregulating filaggrin (FLG). JPYXQFC is typically administered as an oral decoction and has been shown to reduce dermatitis area and severity in animal models[1][2][3][4].

Other names
Jianpi Yangxue Qufeng Compound
02

Targets

NF-κBMYD88 (Myeloid differentiation primary response protein MyD88)TLR4 (Toll-like receptor 4)

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