Jianpi Yishen Formula

Jianpi Yishen Formula (JPYSF) is a traditional Chinese medicine (TCM) herbal prescription widely used in China for the treatment of chronic kidney disease (CKD). It is a multi-herb decoction with a decades-long history of clinical use. The formula typically contains herbs such as Astragali Radix, Atractylodis Macrocephalae Rhizoma, Dioscoreae Rhizoma, Cistanches Herba, Amomi Fructus Rotundus, Salviae Miltiorrhizae Radix et Rhizoma, Rhei Radix et Rhizoma and Glycyrrhizae Radix et Rhizoma[8]. Mechanistically, JPYSF exerts renoprotective effects by modulating tryptophan metabolism and suppressing aryl hydrocarbon receptor signaling[1], enhancing sirtuin 3 expression to regulate mitochondrial dynamics and reduce oxidative stress[2], inhibiting inflammation via suppression of NF-κB signaling[3][5], restoring NAD+ homeostasis to alleviate renal fibrosis[4], and promoting antioxidant activity through Nrf2 pathway activation[5]. The formula has also been studied for its effects on immune modulation and macrophage polarization in CKD models[8].

Brand names

Jianpi Yishen FormulaJPYSF

Other names

Jian-Pi-Yi-Shen formulaJian-Pi-Yi-Shen decoctionJPYS decoction