Drug intelligence / Profile preview

Jianpixiaozhong

Development stage
Unknown
Lead developer
Shanghai University of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Jianpixiaozhong is a Traditional Chinese Medicine (TCM) herbal formulation primarily researched for the treatment of chronic renal diseases, including idiopathic membranous nephropathy (IMN), multidrug-resistant membranous nephropathy (MDR MN), and primary nephrotic syndrome. The formulation is developed based on the TCM therapeutic principle of 'invigorating the spleen and reducing swelling' (Jianpi Xiaozhong). It typically comprises a combination of medicinal herbs such as *Astragalus membranaceus* (Huangqi), *Atractylodes macrocephala* (Baizhu), *Poria cocos* (Fuling), *Alisma plantago-aquatica* (Zexie), and *Plantago asiatica* (Cheqianzi). Its mechanism of action involves immunomodulation and the regulation of the complement system, which helps protect the glomerular filtration barrier and reduce proteinuria. Jianpixiaozhong is frequently administered as oral granules or a decoction and has been studied as a steroid-sparing agent or an alternative for patients who are refractory to conventional immunosuppressive therapies.

Other names
Jianpi Xiaozhong FormulaJianpixiaozhong particlesJianpi Xiaozhong GranulesJianpi Xiaozhong DecoctionJianpi Xiaozhong MixtureJianpi Xiaozhong Tablets
02

Targets

C3C5C4 (Complement component 4)

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