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Jiaotai Wan
- Development stage
- Unknown
- Lead developer
- Jiangsu Provincial Hospital of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Jiaotai Wan is a classic traditional Chinese medicine (TCM) formula composed of two primary botanical ingredients: *Coptis chinensis* (Huanglian) and *Cinnamomum cassia* (Rougui), typically in a 10:1 ratio. It is traditionally indicated for the treatment of insomnia and depression characterized by the "non-interaction of heart and kidney" (xin shen bu jiao) pattern, where it acts to clear heart fire and warm kidney yang. Modern pharmacological research suggests that Jiaotai Wan exerts its therapeutic effects by modulating the hypothalamic-pituitary-adrenal (HPA) axis, regulating neurotransmitter levels such as serotonin and dopamine, and influencing the gut-brain axis. The formula is currently being evaluated in clinical trials for major depressive disorder and insomnia, often as an adjunctive therapy to conventional treatments like fluoxetine.
- Brand names
- JiaotaiwanJiao Tai WanGrand Communication PillCoptis and Cinnamon Formula
- Other names
- Jiao-Tai-WanJiaotai pill交泰丸
02
Targets
ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)IL-6 (Interleukin 6)5-HT (Serotonin receptors)DRD (Dopamine receptors)GR (Glucocorticoid receptor)
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