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Jiawei Guomin Jian
- Development stage
- Unknown
- Lead developer
- Beijing University of Chinese Medicine Third Affiliated Hospital
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Jiawei Guomin Jian is a modified Traditional Chinese Medicine (TCM) decoction based on the classic "Guomin Jian" (Allergy Decoction) formula originally developed by TCM master Zhu Liangchun. The base formula typically includes *Mume Fructus* (Wu Mei), *Schisandrae Chinensis Fructus* (Wu Wei Zi), *Glycyrrhizae Radix et Rhizoma* (Gan Cao), and *Saposhnikoviae Radix* (Fang Feng). The "Jiawei" (modified) version is tailored for specific TCM syndromes; in the context of atopic dermatitis, it is often adjusted to address "Heart Fire and Spleen Deficiency" by adding herbs that clear heat and tonify the spleen. It is primarily used for allergic conditions such as atopic dermatitis, urticaria, and allergic rhinitis, acting through immunomodulatory and anti-inflammatory pathways, including the stabilization of mast cells and regulation of IgE levels.
- Other names
- Jiawei Allergy DecoctionModified Allergy DecoctionModified Guomin Jian加味过敏煎
02
Targets
HRH2 (Histamine H2 Receptor)HRH4 (Histamine H4 receptor)PAR2 (Protease-activated receptor 2)HRH1 (Histamine H1 Receptor)
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