Drug intelligence / Profile preview

Jiawei Tianwang Buxin

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Jiawei Tianwang Buxin (加味天王补心) is an augmented or modified Traditional Chinese Medicine (TCM) formula derived from the classic "Tianwang Buxin Dan" (天王补心丹), also known as "Emperor of Heaven's Pill to Tonify the Heart." This multi-ingredient herbal preparation is traditionally used to address conditions arising from Yin deficiency and blood insufficiency, particularly affecting the heart and kidneys. Its primary indications include insomnia, palpitations, forgetfulness, anxiety, mental fatigue, nocturnal emission, dry stools, and mouth ulcers. While its traditional functions involve nourishing Yin, calming the Spirit, benefiting the Blood, and clearing Heat, modern research suggests it may exert sedative and tranquilizing effects through modulation of neurotransmitters, regulation of inflammatory factors, improvement of oxidative stress, and influence on circadian rhythms. It has also been studied for its potential effects on the HPA axis, GSK3β phosphorylation, and BDNF expression. As a modified formula, its exact composition can vary, but it typically builds upon the core ingredients of Tianwang Buxin Dan.

Brand names
HeartVigor
Other names
加味天王补心Tianwang Buxin DanTianwang Buxin WanEmperor of Heaven's Pill to Tonify the HeartEmperor's TeaTWBXD加減天王補心丹
02

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)AMPK (Adenosine monophosphate–activated protein kinase)CLOCKDRD2 (Dopamine D2 Receptor)MAOA (Monoamine oxidase A)SERT (Sodium-dependent serotonin transporter)STAT3 (Signal Transducer and Activator of Transcription 3)TRPV1 (Transient receptor potential cation channel subfamily V member 1)BDNF (Brain-derived neurotrophic factor)GSK3 (Glycogen synthase kinase 3 beta)COMT (Catechol-O-methyltransferase)

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