jiaweiliujunzitang

JiaWeiLiuJunZiTang (JWLJZT) is a modified traditional Chinese medicine (TCM) herbal formula derived from the classic LiuJunZiTang (Six-Gentlemen Decoction). It is primarily investigated for the treatment of non-motor symptoms (NMS) in patients with idiopathic Parkinson's disease. The base formula consists of six core herbs: Panax ginseng, Atractylodes macrocephala, Poria cocos, Glycyrrhiza uralensis, Citrus reticulata, and Pinellia ternata. The JiaWei (modified) version typically incorporates additional botanical ingredients to address specific neurological and gastrointestinal manifestations of Parkinson's disease, such as constipation, sleep disturbances, and anxiety. JWLJZT is hypothesized to exert its therapeutic effects by modulating the gut-brain axis, potentially through the enhancement of ghrelin receptor signaling and neuroprotective mechanisms. Clinical research, including trials sponsored by the Food and Health Bureau of Hong Kong, has evaluated its safety and efficacy as an adjunctive therapy to standard dopaminergic treatments.

Brand names

JiaWeiLiuJunZiTang

Other names

Modified Six-Gentlemen DecoctionJia-Wei-Liu-Jun-Zi-Tang