Drug intelligence / Profile preview

Jiedu Tongluo Tiaogan Decoction

Development stage: Phase 1
Lead developer: Xiyuan Hospital
Modality: Device-based Delivery → Drug Delivery Systems
Administration: Oral

Overview

Jiedu Tongluo Tiaogan Decoction is a traditional Chinese medicine (TCM) multi-herbal formula used primarily for the management of type 2 diabetes mellitus (T2DM) and its complications. The decoction consists of five main herbal ingredients in specific proportions by weight: - Coptis chinensis Franch (Huanglian) - Radix Rhei Et Rhizome (Dahuang) - Astragalus propinquus Schischkin (Huangqi) - Salvia miltiorrhiza Bunge (Danshen) - Bupleuri Radix (Chaihu) The mechanism of action is pleiotropic and multi-targeted. It has been shown to lower blood glucose levels, improve insulin secretion, reduce insulin resistance, enhance autophagic flux, protect pancreatic β-cells, restore cellular homeostasis, and modulate glucose and lipid metabolism. Molecular studies suggest that it acts through pathways related to lipopolysaccharide/cytokine receptor binding and may inhibit endoplasmic reticulum stress as well as excessive autophagy[2][3][7]. Clinical studies indicate efficacy in improving glycemic control in obese patients with T2DM[3][7].

Brand names: Jiedu Tongluo Tiaogan Formula
Other names: Jiedu Tongluo Tiaogan Formula解毒通络调肝方

Targets

TLR4 (Toll-like receptor 4)Cr (Chromium)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)HIF-1 (Hypoxia-inducible factor 1)IRS1 (Insulin receptor substrate 1)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)

Beyond the preview

Go deeper on Jiedu Tongluo Tiaogan Decoction.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Jiedu Tongluo Tiaogan Decoction.

Explore the full profile