Drug intelligence / Profile preview

Jieduzhuyu Decoction

Development stage
Preclinical
Administration
Oral
01

Overview

Jieduzhuyu Decoction is a traditional Chinese medicine (TCM) herbal formula used primarily for its antitumor, anti-inflammatory, and detoxifying properties. It is composed of multiple medicinal herbs, each contributing to the overall therapeutic effect. The decoction has been studied for its ability to inhibit tumor cell proliferation, induce apoptosis, suppress migration and invasion of cancer cells, and reduce angiogenesis. Mechanistically, it acts by inhibiting the mTOR/HIF-1α/VEGF signaling pathway in cancer models[1]. While specific ingredient lists may vary by source or clinical context, similar TCM formulas often include herbs such as Astragalus (Huang Qi), Atractylodes (Bai Zhu), Ginseng (Ren Shen), Licorice (Gan Cao), Forsythia (Lian Qiao), and Honeysuckle (Jin Yin Hua)[2]. The decoction is not a single chemical entity but a multi-herb combination designed according to TCM principles.

Brand names
Jieduzhuyu Decoction
02

Targets

HIF1A (Hypoxia-inducible factor 1-alpha)mTOR (Mammalian target of rapamycin kinase)

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