Drug intelligence / Profile preview

Jiejing Zhentong Tincture

Development stage
Unknown
Lead developer
Shanghai Xiao Fang Pharmaceutical
Modality
Small Molecules
Administration
Topical
01

Overview

Jiejing Zhentong Tincture (解痉镇痛酊) is a topical over-the-counter (OTC) herbal-chemical combination tincture developed and marketed by Shanghai Xiao Fang Pharmaceutical (formerly Shanghai Yun Jia Huang Pu Pharmaceutical). It is formulated with capsicum extract, Citrus reticulata peel extract, methyl salicylate, and menthol. The tincture is indicated for the relief of neck, shoulder, back, and leg pain resulting from soft-tissue injuries, as well as for the treatment of chilblains (frostbite). Its mechanism of action involves the synergistic effects of its active components: capsaicin (from capsicum extract) acts as a TRPV1 agonist to desensitize nociceptive fibers; methyl salicylate acts as a topical NSAID by inhibiting cyclooxygenases (COX-1 and COX-2) to reduce prostaglandin synthesis and inflammation; and menthol acts as a TRPM8 agonist to provide a cooling sensation and local analgesic effect.

Brand names
Xinlong信龙
Other names
Jie Jing Zhen Tong DingJiejing Zhentong Liniment解痉镇痛酊
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TRPV1 (Transient receptor potential cation channel subfamily V member 1)PGHS-1 (Prostaglandin G/H Synthase 1)TRPM8 (Transient receptor potential cation channel subfamily M member 8)

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