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Jieyu Anshen Formula

Development stage: Preclinical
Modality: Drug Delivery Systems, Small Molecules
Administration: Oral

Overview

Jieyu Anshen Formula is a traditional Chinese medicine combination formula used primarily for the treatment of depression, anxiety, and sleep disorders. It is composed of multiple herbal ingredients—reports indicate up to 16 herbs in some formulations—with the aim of regulating mood and improving neurological function. The formula has demonstrated antidepressant effects in preclinical models of poststroke depression by modulating neurotransmitter systems (monoamines), neuroendocrine function, neuroinflammation pathways (notably NF-κB/IκB-α signaling), and promoting neurogenesis in the hippocampus. Clinical studies also support its use for insomnia and mood disturbances associated with menopause or chronic stress[1][2][3][4][6][7]. Its mechanism involves multi-target modulation including neurotransmitter regulation and anti-inflammatory effects.

Brand names: Jieyu Anshen GranuleJieyu Anshen KeliJieyu Anshen Decoction
Other names: JY解郁安神颗粒 (Jieyu Anshen Keli)解郁安神方 (Jieyu Anshen Fang)解郁安神汤 (Jieyu Anshen Tang)

Targets

SERT (Sodium-dependent serotonin transporter)Nuclear factor kappa-light-chain-enhancer of activated B cells/Inhibitor of nuclear factor kappa B alpha signaling pathway (NF-κB/IκB-α)

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