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Jieyu prescription

Development stage: Preclinical
Lead developer: Wenzhou Hospital of Traditional Chinese Medicine
Administration: Oral

Overview

Jieyu prescription refers to a category of traditional Chinese medicine (TCM) formulations designed to alleviate depression. The specific "self-designed Jieyu prescription" mentioned in the clinical trial context is being investigated by Wenzhou Hospital of Traditional Chinese Medicine for the treatment of post-stroke depression (PSD). Administered orally, its therapeutic effects are believed to involve the modulation of the gut microbiota, influencing the gut-brain axis, and potentially inhibiting neuroinflammation and regulating the hypothalamic-pituitary-adrenal (HPA) axis. Other proposed mechanisms for various Jieyu formulations include increasing levels of neurotransmitters like serotonin and GABA, and neurotrophic factors such as BDNF.

Other names: self-designed Jieyu prescription

Targets

IL-6 (Interleukin 6)VEGFA (Vascular endothelial growth factor A)MYD88 (Myeloid differentiation primary response protein MyD88)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TLR4 (Toll-like receptor 4)ESR1 (ERα)

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