Jin Shui Chen Fei

Jin Shui Chen Fei (JCF) is a Traditional Chinese Medicine (TCM) formula currently under investigation for its potential in treating silicosis. Research has identified an "effective-component compatibility" (ECC) within JCF, comprising isoliquiritin, glycyrrhizic acid, and gallic acid. This specific combination has demonstrated synergistic effects in preclinical models, where it significantly inhibited the expression of inflammatory markers such as TNF-α, IL-1β, IL-6, CD206, and Arg-1 mRNA in mouse alveolar macrophages. Furthermore, ECC-JCF protected lung tissues from alveolar collapse, inflammatory cell infiltration, fibroblast proliferation, and fibrous nodule formation in a silica-induced silicosis mouse model, suggesting its role in regulating inflammation and fibrosis pathways. The ongoing research aims to facilitate the future development of JCF as a new drug for silicosis.