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Jinbuhuan Gutong
- Development stage
- Unknown
- Lead developer
- Guilin Tianhe Pharmaceutical
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Jinbuhuan Gutong is a Traditional Chinese Medicine (TCM) topical formulation, typically presented as a medicated patch or plaster, developed by Guilin Tianhe Pharmaceuticals. It is specifically indicated for the treatment of knee osteoarthritis, bone hyperplasia, and associated joint pain or stiffness. The formulation is centered around the herbal extract Jinbuhuan (derived from *Lycopodium serratum* or *Stephania* species), which contains active alkaloids such as L-tetrahydropalmatine (L-THP). These constituents provide analgesic and anti-inflammatory effects by modulating neurotransmitter receptors and local inflammatory mediators. The patch is designed for transdermal delivery, allowing the herbal active ingredients to penetrate the skin and reach the affected joint tissues to promote blood circulation, reduce swelling, and alleviate chronic pain.
- Brand names
- Jinbuhuan Gutong TieJinbuhuan Gutong Plaster
- Other names
- Jin Bu Huan Gu Tong
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)DRD1 (Dopamine D1 Receptor)DRD2 (Dopamine D2 Receptor)
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