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Jindbi Fang granules
- Development stage
- Unknown
- Lead developer
- Longhua Hospital Shanghai University of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Jindbi Fang granules is a Traditional Chinese Medicine (TCM) formula developed by Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine for the treatment of cervical spondylotic myelopathy (CSM), specifically the "Bi-syndrome" type. The formula is designed to nourish the liver and kidney, relax tendons, and activate collaterals, addressing the underlying TCM pathology of tendon and bone degeneration. It is currently being investigated in a randomized, parallel-group clinical trial (ChiCTR2500113740) to evaluate its efficacy and safety in adults with mild to moderate CSM, with the goal of improving neurological symptoms and functional outcomes compared to placebo.
- Other names
- Jindbi decoctionJinbi Fang granulesJinbi decoction
02
Targets
PPARG (Peroxisome proliferator-activated receptor gamma)STAT3 (Signal Transducer and Activator of Transcription 3)NF-κBKEAP1 (Kelch-like ECH-associated protein 1)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)
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