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Jingfang Gubiao prescription
- Development stage
- Preclinical
- Lead developer
- Shanghai Sixth People’s Hospital
- Administration
- Oral
01
Overview
Jingfang Gubiao prescription is a traditional Chinese medicine (TCM) herbal compound formula developed by Shanghai Sixth People's Hospital for the treatment of mild or asymptomatic COVID-19 (SARS-CoV-2 infection). As a multi-herb botanical mixture, it functions through polypharmacology, targeting various biological pathways involved in viral clearance and symptom management. Clinical evaluation in a retrospective observational study (ChiCTR2200065294) focused on the primary outcome of time to SARS-CoV-2 nucleic acid negativity. Network pharmacology methodology has been employed to identify its active components and molecular targets, characterizing the formulation as a complex natural product mixture rather than a single-target therapeutic.
- Other names
- Jingfanggubiao prescription
02
Targets
NF-κBAKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)STAT3 (Signal Transducer and Activator of Transcription 3)TNFA (Tumor necrosis factor alpha (soluble))
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