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jinghuaweikang
- Development stage
- Unknown
- Lead developer
- Tasly Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Jinghuaweikang (JWC) is a Traditional Chinese Medicine (TCM) patent drug, specifically a botanical formulation consisting of extracts from *Chenopodium ambrosioides* and *Adina pilulifera*. It is the first state-approved Chinese patent medicine for treating gastritis and peptic ulcers caused by *Helicobacter pylori* (H. pylori) infection. The drug exerts its therapeutic effects through multiple mechanisms: it possesses direct antibacterial activity against H. pylori (including drug-resistant strains) by inhibiting biofilm formation, and it reduces gastric mucosal inflammation by inhibiting the NF-κB and MAPK signaling pathways. Additionally, JWC has been shown to modulate the intestinal microbiota. It is uniquely endorsed by Chinese clinical guidelines for the management of refractory H. pylori infections, typically as an adjunct to bismuth quadruple therapy.
- Brand names
- Jinghuaweikang
- Other names
- Jinghua WeikangJing Hua Wei KangJWCJinghuaweikang capsule
02
Targets
MEKNF-κB
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