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jinkuishenqiwan

Development stage: Unknown
Lead developer: Beijing University of Chinese Medicine Third Affiliated Hospital
Administration: Oral

Overview

Jinkuishenqiwan (also known as Jin Kui Shen Qi Wan or Golden Cabinet's Kidney Qi Pill) is a classic Traditional Chinese Medicine (TCM) formula first recorded in the "Synopsis of Prescriptions of the Golden Chamber" by Zhang Zhongjing. It is designed to warm and tonify kidney yang. The formula is a combination of eight herbal ingredients: Rehmannia glutinosa, Dioscorea opposita, Cornus officinalis, Alisma orientale, Poria cocos, Paeonia suffruticosa, Cinnamomum cassia, and Aconitum carmichaelii. While traditionally used for conditions characterized by kidney yang deficiency—such as lower back pain, edema, and urinary difficulties—it is also being investigated for its efficacy in treating depression, particularly when the condition presents with liver qi stagnation and kidney qi deficiency. Its therapeutic effects are thought to be mediated through the regulation of the hypothalamic-pituitary-adrenal (HPA) axis and the modulation of neuroendocrine functions.

Brand names: Jinkui Shenqi WanJinkui Shenqi Pills
Other names: Jin Kui Shen Qi WanGolden Cabinet's Kidney Qi PillShen Qi WanKidney Qi Pill from the Golden Cabinet

Targets

Aβ (Amyloid-beta peptides and aggregates)ERBB2 (Erb-b2 receptor tyrosine kinase 2)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)EGFR T790M (Epidermal growth factor receptor T790M mutant)MHC II (Major histocompatibility complex class II receptor)

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