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jitai
- Development stage
- Unknown
- Lead developer
- Shanghai Mental Health Center
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Jitai is a Traditional Chinese Medicine (TCM) formulation primarily used in China for the treatment of opioid withdrawal symptoms and the prevention of relapse in heroin-dependent individuals. It is composed of approximately 15 herbal ingredients, including *Corydalis yanhusuo*, *Salvia miltiorrhiza*, *Panax ginseng*, and *Angelica sinensis*. The formulation is designed to alleviate physical withdrawal symptoms, reduce psychological cravings, and restore physiological balance post-detoxification. Clinical studies, often led by institutions like the Shanghai Mental Health Center, have evaluated its efficacy both as a monotherapy and in combination with psychosocial interventions. Its mechanism is complex and multi-targeted, involving the modulation of the endogenous opioid system, dopaminergic neurotransmission, and the hypothalamic-pituitary-adrenal (HPA) axis. Jitai is regulated as a pharmaceutical product in China and is typically administered orally in tablet or capsule form.
- Brand names
- Jitai
- Other names
- Jitai tabletJitai capsuleJitai-Pian
02
Targets
DRD (Dopamine receptors)MOR (Mu opioid receptor)
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