Drug intelligence / Profile preview

Jiu-wei-zhen-xiao

Development stage: Phase 1
Lead developer: Beilu Pharmaceutical
Administration: Oral

Overview

Jiu-wei-zhen-xiao is a granule formulation derived from nine different kinds of traditional Chinese medicine. It is being investigated for the treatment of advanced, unresectable hepatocellular carcinoma (HCC). A pilot single-arm clinical trial has been completed to assess its therapeutic efficacy, with primary endpoints focusing on overall survival and secondary endpoints including progression-free survival, quality of life, liver function, coagulation function, tumor size, traditional Chinese medicine syndrome improvement, pain reduction, and toxicity profile.

Other names: Jiu-wei-zhen-xiao Granule

Targets

HTR2A (5-hydroxytryptamine receptor 2A)MAOA (Monoamine oxidase A)DAT (Dopamine plasma membrane transport protein)MAOB (Monoamine oxidase B)HTR3A (5-hydroxytryptamine receptor 3A)DRD2 (Dopamine D2 Receptor)GABAA (Gamma-aminobutyric acid receptor)CASP3 (Caspase-3)SERT (Sodium-dependent serotonin transporter)

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