JJH201501

JJH201501 is a deuterated small molecule antidepressant developed by Jiangsu Jibeier Pharmaceutical. It is a deuterated modification of vortioxetine, designed to improve metabolic stability and bioavailability while reducing toxicity through the reduction of oxidative metabolism. The drug functions through a multi-receptor mechanism, acting as a serotonin reuptake inhibitor (SRI), norepinephrine transporter (NET) inhibitor, and dopamine reuptake inhibitor. Clinical data from Phase 3 trials indicate that JJH201501 at 10mg and 15mg doses demonstrates efficacy in treating depression comparable to 20mg of vortioxetine hydrobromide, with a potentially superior safety profile and lower effective dosage requirements.

Other names

deuterated vortioxetinedeuterated antidepressant