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JK5G
- Development stage
- Phase 1
- Lead developer
- Japan Kyowa Industrial
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
JK5G is a postbiotic formulation developed to modulate the gut microbiota and improve outcomes in patients with advanced non-small-cell lung cancer (NSCLC) receiving immune checkpoint inhibitors (ICIs). In clinical studies, administration of JK5G alongside PD-1 inhibitor-based immunotherapy and chemotherapy was associated with reduced incidence of immune-related adverse events (irAEs), improved quality of life, better nutritional status, and amelioration of tumor microenvironment inflammation. The mechanism is believed to involve modulation of the intestinal microbiome, which in turn influences systemic immunity and response to cancer immunotherapy. Clinical trials have demonstrated that patients receiving JK5G had lower rates of anemia, decreased lymphocyte count, appetite loss, nausea, asthenia, and other adverse effects compared to controls[1][2][6].
- Brand names
- JK5GJK-5GJK 5G
- Other names
- JK5G postbioticsJK-5G postbioticsJK 5G postbiotics
02
Targets
FFAR2FFAR3 (Free fatty acid receptor 3)HCAR2 (Hydroxycarboxylic acid receptor 2)HDAC (HDAC family)TLR (Toll-like receptors)
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