Drug intelligence / Profile preview

JLC056

Development stage
Preclinical
Lead developer
Jecho Laboratories
Modality
Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

JLC056 is a bispecific antibody-drug conjugate (ADC) being developed by Jecho Laboratories. It is designed to simultaneously target Tissue Factor (TF) and Epidermal Growth Factor Receptor (EGFR), two proteins that are frequently overexpressed in a variety of solid tumors. By dual-targeting these antigens, JLC056 aims to deliver a cytotoxic payload specifically to tumor cells, potentially enhancing therapeutic efficacy and reducing off-target toxicity compared to monospecific ADCs. This approach may also help overcome resistance mechanisms associated with single-target therapies. JLC056 is currently in the IND-enabling stage of development for oncology indications.

02

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