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JLC059
- Development stage
- Preclinical
- Lead developer
- Jecho Laboratories
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
JLC059 is an investigational bispecific antibody-drug conjugate (ADC) developed by Jecho Laboratories. It is designed to simultaneously target Glypican-3 (GPC3) and Programmed Death-Ligand 1 (PD-L1). GPC3 is a cell-surface glycoprotein frequently overexpressed in hepatocellular carcinoma (HCC) and other solid tumors, while PD-L1 is a well-characterized immune checkpoint protein. By utilizing a bispecific antibody architecture, JLC059 aims to selectively deliver a cytotoxic payload to tumor cells expressing these markers, potentially increasing therapeutic precision and overcoming resistance mechanisms associated with single-target therapies. As of early 2024, the candidate is in the IND-enabling stage of development for the treatment of solid tumors.
- Other names
- GPC3/PD-L1 ADC
02
Targets
GPC3 (Glypican-3)CD274 (Programmed cell death protein 1 ligand 1)
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