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JNJ-53718678 + JNJ-64417184
- Development stage
- Phase 1
- Lead developer
- Janssen Research & Development
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
JNJ-53718678 + JNJ-64417184 is an **oral combination of two investigational small molecules** being developed for the treatment of **respiratory syncytial virus (RSV) infection**. JNJ-53718678 is a **fusion inhibitor**, which blocks the fusion of the virus with host cell membranes, inhibiting viral entry and propagation. JNJ-64417184 is a **viral polymerase inhibitor**, targeting the production of viral proteins and thereby blocking replication. Both compounds have demonstrated activity against RSV by different mechanisms, and combination therapy is hypothesized to improve antiviral efficacy by targeting two essential steps in the viral life cycle. Both drugs are in early-phase clinical trials and have been primarily studied by Janssen (Johnson & Johnson companies)[1][3][4][7][10].
- Other names
- JNJ-8678 + JNJ-64417184
02
Targets
RSV F (Respiratory syncytial virus fusion protein)RSV L (Respiratory syncytial virus L protein)
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