Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
JNJ-70099731
- Development stage
- Phase 1
- Lead developer
- Janssen Research & Development
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
JNJ-70099731 is a radiolabeled small molecule developed by Janssen Pharmaceutical as a positron emission tomography (PET) imaging ligand. It specifically targets the P2X7 receptor, an ATP-gated ion channel that plays a critical role in neuroinflammation and the release of pro-inflammatory cytokines like IL-1β. The tracer is designed to quantify P2X7 receptor expression in the brain, serving as a biomarker for neuroinflammatory processes in conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Clinical studies have focused on its brain kinetics, distribution, and radiation dosimetry in healthy volunteers to validate its utility as a diagnostic tool for monitoring microglial activation in vivo.
- Other names
- [18F]JNJ-70099731[18F]-JNJ-70099731
02
Targets
MGLL (Monoacylglycerol lipase)
Beyond the preview
Go deeper on JNJ-70099731.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on JNJ-70099731.