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JNJ-7706621
- Development stage
- Preclinical
- Lead developer
- Johnson & Johnson
- Modality
- Small Molecules
- Administration
- Oral, Intraperitoneal
01
Overview
**JNJ-7706621** is a small molecule, dual inhibitor targeting both cyclin-dependent kinases (CDKs) and Aurora kinases. It potently inhibits CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, and Aurora kinase A/B, resulting in disruption of cell cycle progression. In preclinical studies, JNJ-7706621 blocks tumor cell proliferation by causing G2/M phase arrest, endoreduplication, and apoptotic cell death, while showing reduced toxicity toward normal cells. The drug has demonstrated antitumor activity in xenograft models across multiple cancer types and can synergistically overcome resistance to radioimmunotherapy in activated B cell–like diffuse large B cell lymphoma. JNJ-7706621 has not progressed to clinical trials[1][3][5][7].
- Other names
- Aurora Kinase Inhibitor II4-(4'-Benzamidoanilino)-6,7-dimethoxyquinazoline
02
Targets
AURKA (Aurora kinase A)CDK1 (Cyclin-dependent kinase 1)Cyclin-dependent kinase 6–cyclin D1 complexCDK3 (Cyclin-dependent kinase 3)VEGFR2 (Vascular endothelial growth factor receptor 2)AURKB (Aurora kinase B)CDK4 (Cyclin-dependent kinase 4)GSK3 (Glycogen synthase kinase 3 beta)JAK2 JH2 (Janus kinase 2 (JAK2) JH2 pseudokinase domain)Cyclin-dependent kinase 2-cyclin E/A complexVEGFR3 (Vascular endothelial growth factor receptor 3)FGFR2 (Keratinocyte growth factor receptor)FGFR1 (Fibroblast growth factor receptor 1)TEK (Tie2)
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