JNJ54173717

JNJ54173717 is a high-affinity, selective antagonist of the **P2X7 receptor (P2X7R)**, developed primarily as a **PET radiotracer** for in vivo quantification of P2X7R expression in the brain. P2X7R is an ATP-gated cation channel implicated in neuroinflammation–a process associated with neurodegenerative diseases and excitotoxicity. JNJ54173717 demonstrates nanomolar affinity for both human and rodent P2X7R, crosses the blood-brain barrier, and selectively binds to P2X7R, enabling the imaging of neuroinflammation and P2X7R upregulation using PET. It is not currently used as a therapeutic but is investigated as a molecular imaging agent, especially for neuroinflammatory and neurodegenerative disorders such as Parkinson's disease[4][3][7][5].

Other names

[11C]JNJ54173717[^11C]JNJ-54173717[11C]JNJ-717