JNK-IN-8

JNK-IN-8 is a selective, potent, and irreversible small molecule inhibitor of c-Jun N-terminal kinases (JNK1, JNK2, and JNK3) belonging to the mitogen-activated protein kinase (MAPK) family. It covalently binds a conserved cysteine residue in the kinase active site, causing a conformational change that blocks substrate binding and kinase activity. JNK-IN-8 effectively inhibits JNK signaling with IC50 values of 4.67 nM for JNK1, 18.7 nM for JNK2, and 0.98 nM for JNK3, with high specificity and minimal activity against other kinases. It is widely used as a research tool to study JNK-mediated processes such as stress response, apoptosis, T cell differentiation, cancer biology, inflammation, and neurodegenerative disease pathways[1][2][3][6][7].

Other names

JNK-IN-8JNK-IN8JNK-IN 8JNK Inhibitor XVI3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamideJNK-IN-8 USP/EP/BP