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JOINS
- Development stage
- Phase 4
- Lead developer
- SK Chemicals
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
JOINS (SKI306X) is a botanical drug developed by SK Chemicals, approved in South Korea for the treatment of osteoarthritis and rheumatoid arthritis. It is a standardized extract derived from three medicinal plants: *Clematis mandshurica*, *Trichosanthes kirilowii*, and *Prunella vulgaris*. The drug exhibits a multi-target mechanism of action, providing anti-inflammatory, analgesic, and cartilage-protective (chondroprotective) benefits. It works by inhibiting the expression and activity of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β), as well as matrix metalloproteinases (MMPs) that degrade the extracellular matrix of cartilage. JOINS was the first herbal medicine to be approved as a prescription drug by the Korean Ministry of Food and Drug Safety.
- Brand names
- JOINS
- Other names
- Joins tablet
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ALOX5 (Arachidonate 5-lipoxygenase)IL1B (Interleukin-1 beta)MMP12 (Macrophage Metalloelastase)TNFA (Tumor necrosis factor alpha (soluble))
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