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JointAlive
- Development stage
- Unknown
- Lead developer
- Chenland Nutritionals
- Modality
- Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
JointAlive is a proprietary traditional Chinese medicine (TCM) formulation developed for the treatment of knee osteoarthritis. It consists of a standardized blend of extracts from three flowering plants endemic to China: *Epimedium brevicornum* Maxim (leaves), *Dioscorea nipponica* Makino (rhizome), and *Salvia miltiorrhiza* Bunge (root and rhizome). The primary bioactive constituent is icariin, a flavonoid glycoside that exhibits antioxidant and anti-inflammatory properties. JointAlive is designed to alleviate symptoms of pain and stiffness and improve joint functionality by suppressing pro-inflammatory pathways, such as the NF-κB signaling cascade, and protecting articular cartilage from catabolic degradation. It has undergone safety, toxicity, and efficacy evaluations in both preclinical models and human clinical trials.
- Brand names
- JointAlive
02
Targets
IL-6 (Interleukin 6)NF-κBIL1B (Interleukin-1 beta)TNFA (Tumor necrosis factor alpha (soluble))
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