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JS019
- Development stage
- Phase 1
- Lead developer
- Eirene Biotech
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
JS019 is a recombinant, fully human (humanized) monoclonal antibody that targets the cell surface receptor CD39 (also known as ectonucleoside triphosphate diphosphohydrolase-1 or ENTPD1). CD39 is an enzyme involved in the conversion of extracellular ATP to adenosine, which plays a key role in creating an immunosuppressive tumor microenvironment. By inhibiting CD39, JS019 aims to modulate immune responses and exert antineoplastic effects. It is being developed for use as an immunomodulatory and antitumor agent, with clinical trials currently focused on advanced solid tumors and lymphomas. The drug is administered intravenously[1][3][4][7].
- Other names
- anti-CD39 monoclonal antibody JS019anti-CD-39 monoclonal antibody JS019anti-CD 39 monoclonal antibody JS019
02
Targets
ENTPD1 (Ectonucleoside triphosphate diphosphohydrolase 1)
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