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JSKN016 + carboplatin + ivonescimab
- Development stage
- Unknown
- Lead developer
- AlphaMab Oncology
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
JSKN016 + carboplatin + ivonescimab is a triple combination therapy currently being investigated in clinical trials primarily for advanced malignant solid tumors, HER2-negative breast cancer, and non-small cell lung cancer. JSKN016 is a bispecific antibody-drug conjugate (ADC) targeting HER3 and TROP2, which delivers a cytotoxic topoisomerase I inhibitor (TOPIi) upon binding, causing tumor cell apoptosis and exhibiting a bystander effect on antigen-negative cells[1][2][4]. Carboplatin is a platinum-based chemotherapeutic agent that induces DNA crosslinking, leading to cell death. Ivonescimab is a bispecific monoclonal antibody targeting PD-1 and VEGF, functioning as a checkpoint inhibitor with anti-angiogenic properties. This combination is designed to simultaneously target tumor cell receptors, induce DNA damage, and suppress immune checkpoint and angiogenesis pathways for enhanced antitumor effect.
- Other names
- JSKN016JSKN-016JSKN 016carboplatinivonescimab
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)ERBB3 (Erb-b2 receptor tyrosine kinase 3)TACSTD2 (Tumor-associated calcium signal transducer 2)TOP1 (DNA Topoisomerase I)DNA
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