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JSKN016HC
- Development stage
- Phase 1
- Lead developer
- AlphaMab Oncology
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Subcutaneous
01
Overview
JSKN016HC is a subcutaneously injectable formulation of JSKN016, a first-in-class bispecific antibody-drug conjugate (ADC) targeting both HER3 (receptor tyrosine-protein kinase erbB-3) and TROP2. Developed by Jiangsu Alphamab Biopharmaceuticals using a proprietary glycan-specific conjugation platform, JSKN016HC is designed to treat advanced malignant solid tumors. By dual-targeting these two frequently overexpressed tumor antigens, the drug aims to enhance tumor specificity and overcome resistance associated with single-target therapies. The subcutaneous administration of JSKN016HC offers a potentially more convenient delivery method compared to traditional intravenous infusions of ADCs.
02
Targets
ERBB3 (Erb-b2 receptor tyrosine kinase 3)TACSTD2 (Tumor-associated calcium signal transducer 2)
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